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Literature/References These abstracts are provided for your reference regarding cystic fibrosis testing. We encourage you to seek out the complete documents when available. The Cystic Fibrosis mutation “arms race”: when less is more Is Cystic Fibrosis Carrier Screening Cost Effective?

Web Resources The following external websites offer information about cystic fibrosis, including scientific facts about the disease, treatment, and the effort to find a cure: Cystic Fibrosis Foundation Boomer Esiason Foundation March of Dimes American College of Obstetricians and Gynecologists Medline Plus – Cystic Fibrosis

The Cystic Fibrosis mutation “arms race”: when less is more

Dr. Wayne W. Grody, et al.
Genetics in Medicine (November 2007)
Vol. 9, No. 11
Pages 739 – 744

Is Cystic Fibrosis Carrier Screening Cost Effective?

S. Wei, et al.
Community Genetics (2007)
Vol. 10
Pages 103 – 109

Between 2001 and 2005, 6,166 females underwent cystic fibrosis (CF) carrier screening at our institution. Only 36% were Caucasian. We identified 143 carrier females and subsequently tested 85 of their partners. The observed carrier frequency was not significantly different than expected for any racial or ethnic group tested. We identified 6 positive couples (5 Caucasian, 1 Arab American) and 1 affected fetus. In just under 4 years, our institution spent approximately USD 334,000 on CF population screening. Comparing this to the lifetime medical cost for a CF patient, CF population-based carrier screening is cost effective at our institution, despite the high number of non-Caucasians being screened.